BIOTICS RESEARCH SUPPLEMENTS

However, over-the-counter thyroid glandular supplementations are also available.Biotics Research has been manufacturing glandular supplements since the 1980’s.

There glandular products are prepared strictly from USDA inspected bovine and porcine tissues and are certified BSE-free. GTA-Forte II contains 20 milligrams of porcine thyroid glandular (T3) along with 10 milligrams of zinc and I milligram of copper which are not present in GTA. Use for primary thyroid hypo-function when body temperature (a sign of low metabolism and hypothyroid) are at or below 97.8 or if TSH is elevated.

Riboflavin (B2) (as riboflavin-5-phosphate) . . . . . . . . . . . . . . . . . 3.4 mg

Niacin (as niacinamide) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 mg

Vitamin B6 (as pyridoxal-5-phosphate) . . . . . . . . . . . . . . . . . . . . . . 6 mg

Folate (as folic acid). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 400 mcg

Vitamin B12 (as hydroxycobalamin). . . . . . . . . . . . . . . . . . . . . . . . 12 mcg

Biotin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 300 mcg

Pantothenic Acid (as calcium pantothenate). . . . . . . . . . . . . . . . . 20 mg

Calcium (as calcium citrate) . . . . . . . . . . . . . . . . . . . . . . . . . . . 300 mg

Magnesium (as magnesium malate, glycinate) . . . . . . . . . . . . . 300 mg Zinc (as zinc gluconate) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 mg

Manganese (as manganese gluconate) . . . . . . . . . . . . . . . . . . . . . 5 mg

Purified Chondroitin Sulfate . . . . . . . . . . . . . . . . . . . . . . . . . . . . 200 mg

Boron (as calcium borogluconate) . . . . . . . . . . . . . . . . . . . . . . . . . 3 mg

Silicon (from Saccharum officinarum extract) . . . . . . . . . . . . . . 100 mcg

Superoxide Dismutase (from vegetable culture) . . . . . . . . . . . . . . 30 mcg

Catalase (from vegetable culture) . . . . . . . . . . . . . . . . . . . . . . . . 30 mcg

Each tablet supplies:

Folic Acid . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5,000 mcg

Vitamin B12 (as cobalamin). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 mcg

Superoxide Dismutase (from vegetable culture) . . . . . . . . . . . . . . 20 mcg

Catalase (from vegetable culture) . . . . . . . . . . . . . . . . . . . . . . . . 20 mcg

RECOMMENDATION: One (1) tablet each day as a dietary supplement or as otherwise directed by a healthcare professional.

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Product Information: Tablets per bottle: 60

Contents:

Each Tablet Supplies:

Vitamin B1 (thiamine mononitrate) 2 mg, Vitamin B2 (riboflavin) 2 mg, Vitamin B6 (pyridoxine HCl) 5 mg, Niacinamide 10 mg, Pantothenic acid 40 mg, Vitamin C (ascorbic acid) 100 mg, Vitamin E (emulsified d-alpha tocopheryl acetate) 30 IU, Copper (gluconate) 0.5 mg, Lithium (vegetable culture) 20 mcg, Magnesium (aspartate) 25 mg, Manganese (gluconate) 3 mg, Rubidium (vegetable culture) 20 mcg, L-tyrosine 100 mg, Achyranthes (root) 20 mg, Basil (leaves) 20 mg, Asiatic Dogwood (fruit) 20 mg, Sichuan Teasel (root) 20 mg, Ginkgo biloba (leaves) 20 mg, Gotu-kola (aerial part) 20 mg, Commiphora mukul (gum resin) 20 mg, Tinospora cordifolia (stem) 20 mg, Schisandra chinensis (fruit) 20 mg

Recommendation:

2 tablets per day or as recommended by your healthcare professional.

These statements have not been evaluated by the US Food and Drug Administration. This product is not claimed to diagnose, treat, cure, or prevent any disease.

Biotics Research Corporation is widely recognized for its emulsified fat-soluble nutrients and other lipids, microemulsified with the practical objective of increased absorption and bioavailability. This technology has now been applied to the oil of oregano. By emulsifying oregano extracts, the effective surface area of the oil is dramatically increased. An additional step was to apply a sustained release mechanism to A.D.P.™, assuring a slow release throughout the digestive tract. The combined effect of emulsification and sustained release is to enhance intestinal exposure to the essential oil.

Basic concepts and physiologic function:

Oregano oil is a normal part of the human diet and has been safely consumed for millennia. Because of its ability to kill yeast and bacteria, oregano oil has been used as a food preservative, and it has recently been shown to possess antioxidant activity.

Product Information:

Capsules per bottle: 60

Each A.D.P. tablet supplies:

Standardized extract of oregano (50 mg) in emulsified form, incorporated into a sustained release mechanism.

Suggested usage:

One (1) to two (2) tablets with each meal and at bedtime as a dietary supplement or as otherwise directed by a health care professional.

Recommended additional supplementation:

Lactozyme™ (providing lactobacillus acidophilus and bifidus), two (2) to three (3) tablets twice daily; or BioDophilus-FOS™, one-half to one (1) teaspoon in a glass of water, between meals, to help normalize intestinal bacteria.

Biotics Research Corporation is widely recognized for its emulsified fat-soluble nutrients and other lipids, microemulsified with the practical objective of increased absorption and bioavailability. This technology has now been applied to the oil of oregano. By emulsifying oregano extracts, the effective surface area of the oil is dramatically increased. An additional step was to apply a sustained release mechanism to A.D.P.™, assuring a slow release throughout the digestive tract. The combined effect of emulsification and sustained release is to enhance intestinal exposure to the essential oil.

Basic concepts and physiologic function:

Oregano oil is a normal part of the human diet and has been safely consumed for millennia. Because of its ability to kill yeast and bacteria, oregano oil has been used as a food preservative, and it has recently been shown to possess antioxidant activity.

Product Information:

Capsules per bottle: 60

Each A.D.P. tablet supplies:

Standardized extract of oregano (50 mg) in emulsified form, incorporated into a sustained release mechanism.

Suggested usage:

One (1) to two (2) tablets with each meal and at bedtime as a dietary supplement or as otherwise directed by a health care professional.

Recommended additional supplementation:

Lactozyme™ (providing lactobacillus acidophilus and bifidus), two (2) to three (3) tablets twice daily; or BioDophilus-FOS™, one-half to one (1) teaspoon in a glass of water, between meals, to help normalize intestinal bacteria.

Basic concepts and physiologic function

Vitamin A is necessary for healthy function of the immune system and for the maintenance of epithelial tissue such as that found in the eye, gastrointestinal tract and skin.

Product Information:

Servings per bottle: 1 Fluid Oz. (750 drops)

Contents:

Each drop supplies:

Vitamin A (as palmitate) 12,500 IU, Bio-Ae-Mulsion Forte™ is an oil-in-water emulsion, Vitamin A and E oils have been dispersed into microscopic particles to aid in absorption and assimilation.

WARNING: FOR ADULTS ONLY.

Use only as recommended unless otherwise directed by a health care professional. Excessive consumption of vitamin A has been shown to cause serious health problems.

RECOMMENDATION: One (1) drop each day as a dietary supplement.

Basic concepts and physiologic function

Product Information:Contains: 2 Fluid Oz.

Contents:

Five (5) drops supply the following amino acids in a base of glycerol and water:

Proprietary blend: 55 mg: L-Alanine, L-Arginine, Glycine, L-Lysine, L-Proline, L-Histidine, L-Serine, L-Threonine, L-Valine.

RECOMMENDATION: Five (5) drops under the tongue, one (1) to three (3) times each day as a dietary supplement or as otherwise directed by a health care professional.

B-vitamins facilitate and maintain physiologic function by acting as enzyme co-factors. In other words, in order for enzymes to function in the human body to carry out normal processes, these enzymes must have their specific cofactors, such as vitamins.

Deficiencies and insufficiencies of vitamins are common in the general population since, as noted in a recent article in Journal of the American Medical Association*, "suboptimal intake of some vitamins...is ... common in the general population... Most people do not consume an optimal amount of all vitamins by diet alone. Pending strong evidence of effectiveness from randomized trials, it appears prudent for all adults to take vitamin supplements."

Vitamins are obtained from the diet, and they function in tandem in their roles in the interconnected physiologic processes of the body. Therefore, vitamin deficiencies rarely occur in isolation - generally, when someone is found to be deficient in a single vitamin, they are also deficient in other vitamins, too, and "Combined deficiencies of B vitamins exacerbate minor deficiencies in any single vitamin."**

**Merril AH, Burnham FS. Chapter 18. Vitamin B-6. In: Brown ML. Present Knowledge in Nutrition. Sixth Edition. Washington DC; International Life Sciences Institute: 1990, pages 155-162

Product Information: Capsules per bottle: 180

Certain doctor groups have specifically requested that we formulate a low-potency multivitamin for use in multiple doses throughout the day. For more potent multivitamin formulations, please see Bio-B Complex and Bio-Multi Plus.

Contents per three (3) tablets:

Thiamin (B1) (as cocarboxylase) 1.5 mg, Riboflavin (B2) (as riboflavin-5-phosphate) 1.7 mg, Niacin (as niacinamide) 20 mg, Vitamin B6 (as pyridoxal-5-phosphate) 2 mg, Folic Acid 400 mcg, Vitamin B12 (as cyanocobalamin) 6 mcg, Biotin 300 mcg, Pantothenic Acid (as calcium pantothenate) 10 mg, Superoxide Dismutase (vegetable culture source) 60 mcg, Catalase (vegetable culture source) 60 mcg.

RECOMMENDATION: One (1) to three (3) tablets three (3) times each day as a dietary supplement or as otherwise directed by a health care professional.

In healthy people, the body converts GLA from linoleic acid (LA), the most abundant n6 fatty acid in the average western diet. GLA is the precursor for arachadonic acid, dihomogamma linolenic acid (DGLA) and of certain prostaglandins (PGE1) which in turn play important roles in maintaining health.

A number of dietary factors can affect the conversion of LA to GLA. Among others, they include excessive intake of trans fatty acids, common in western diets, which can inhibit enzymatic reactions (delta-6-desaturase activity) that affect the LA to GLA conversion process. Niacin (B3), pyridoxal 5-phosphate (B6), vitamin C and magnesium are cofactors for delta 6-desaturase. Excessive alcohol intake can also interfere, as can zinc deficiency, as zinc is required for the conversion of LA to GLA as well. Additionally, high intake of sugar and refined carbohydrates, diabetic conditions and aging can all negatively affect the conversion of LA to GLA.

PGE1 prostaglandins are vital for maintaining cardiovascular health. They prevent blood platelets from sticking together and help regulate cholesterol production in the liver. They also help the body utilize the glucose regulating hormone insulin and help protect the body against inflammatory immunoresponse conditions. Because PGE1 prostaglandins, so vital for maintaining health, are dependent on adequate GLA for their production, it may be beneficial to provide supplemental GLA to those suspected of having low GLA levels due to an inadequate diet.

Product Information:

Capsules per bottle: 100

What this product does:

Each capsule supplies Blackcurrant Seed oil, providing 40 mg of GLA.

Basic concepts and physiologic function

Vitamin C is biologically available in several forms. Many people prefer the buffered form of vitamin C.

The biologic effects and benefits of vitamin C are significant and innumerable.

Product Information: Tablets per bottle: 100

Contents:

Each tablet supplies:

vitamin C (calcium, sodium, potassium and magnesium ascorbates) 500 mg, Citrus Bioflavonoids 100 mg, Calcium (from calcium ascorbate) 50 mg, Magnesium (from magnesium ascorbate) 32 mg, Superoxide dismutase (from vegetable culture) 10 mcg, Catalase (from vegetable culture) 10 mg.

Recommendation: one-three tablets per day or more as recommended by your healthcare professional.

Basic concepts and physiologic function

Vitamin C is biologically available in several forms. Many people prefer the buffered form of vitamin C.

The biologic effects and benefits of vitamin C are significant and innumerable.

Product Information: Tablets per bottle: 100

Contents:

Each tablet supplies:

vitamin C (calcium and magnesium ascorbates) 850 mg, Calcium (from calcium ascorbate) 50 mg, Magnesium (from magnesium ascorbate) 32 mg, Superoxide dismutase (from vegetable culture) 15 mcg, Catalase (from vegetable culture) 15 mg, Recommendation: one tablet per day or more as recommended by your healthcare professional.

Chlorella is a naturally occurring algae that has a long history of consumption by humans and is a rich source of many nutrients. Rather than being a single specific nutrient with a specific application, Chlorella enjoys a wide range of applications.

Product Information: Capsules per bottle: 180 capsules

More information coming soon!

Basic concepts and physiologic function

Recent studies have shown that magnesium intake is generally below the US RDA/RDI for most adults, and magnesium deficiency is very common among certain subgroups in America. Magnesium is necessary for cardiovascular health, proper neurologic function, and for the function of many enzyme systems, including those which are involved in fatty acid metabolism and liver detoxification.

Calcium is also necessary for proper neurologic function, cardiovascular health, and of course for promotion and maintenance of bone strength. Additionally, calcium and magnesium intake are inversely proportional to the severity of premenstrual syptoms.

Beyond their basic nutritional functions, many vitamins and minerals are being shown to help reduce the risk of chronic illnesses. A recent review article published in the Journal of the American Medical Association recommends that all adults supplement their diet with additional vitamins and minerals--Fairfield KM, Fletcher RH. Vitamins for chronic disease prevention in adults: scientific review. JAMA. 2002 Jun 19;287(23):3116-26

Product Information: Tablets per bottle: 100

Contents:

Each tablet supplies:

Calcium gluconate 200 mg (elemental calcium 18 mg), Magnesium gluconate 100 mg (elemental magnesium 5 mg), Potassium chloride 100 mg (elemental potassium 52 mg).

RECOMMENDATION: One (1) tablet one (1) to three (3) times each day as a dietary supplement or as otherwise directed by a health care professional.

CoQ-10 tends to be one of the more expensive supplements on the market, and the absorption from oral supplementation is known to be inefficient. Therefore, if absorption can be increased by special manufacturing techniques, then a lower dose can be utilized to attain at least the same blood level and at least the same clinical effectiveness. The combination of cost reduction and improved absorption with Biotics CoQ-10 is obviously superior to using a product with inferior absorption and which therefore requires a higher dose and thus more expense. We have studied, documented, and published the results of research showing that emulsification of CoQ-10 leads to improved absorption and improved cost-effectiveness. Emulsification of CoQ-10 more than doubles absorption, such that 30 mg of CoQ-10 in emulsified form from Biotics is equivalent to approximately 80 mg of non-emulsified, dry CoQ-10.

Basic concepts and physiologic function

CoQ-10 is necessary for one of the terminal steps in the electron transport chain in the process of energy (ATP) production). Thus, as a necessary component of mitochondria for the production of energy, CoQ-10 has potential to improve physiologic function in a number of conditions associated with impaired mitochondrial function.

Coenzyme Q10 was discovered and manufactured for the first time by Dr. Karl Folkers of the University of Texas in Austin. All vitamins are enzyme cofactors, and Dr. Folkers later stated that he should have used the name "vitamin Q" rather "coenzyme Q" to avoid misunderstandings about the use of this substance and to expedite its utilization in healthcare.

Folkers worked with an international team of colleagues and found many clinical applications for CoQ-10. They found that patients with idiopathic dilated cardiomyopathy - a form of heart failure - were universally deficient in CoQ-10. They conducted clinical trials with these patients and reported positive results.

Product Information: Tablets per bottle: 60 Product code: # 2616

Contents:Each tablet supplies:

Coenzyme Q10 30 mg in emulsified form., Superoxide Dismutase (from vegetable culture) 30 mcg, Catalase (from vegetable culture) 30 mcg.

RECOMMENDATION: One (1) tablet each day as a dietary supplement or as otherwise directed by a health care professional.

Basic concepts and physiologic function

This product is intended to provide nutritional support for the adrenal gland.

Product Information:Capsules per bottle: 60

Contents: Each tablet supplies:

Neonatal Adrenal complex (bovine) 80 mg, Superoxide Dismutase (from vegetable culture) 20 mcg, Catalase (from vegetable culture) 20 mcg.

RECOMMENDATION: One (1) tablet one (1) to three (3) times each day as a dietary supplement or as otherwise directed by a health care professional.

Basic concepts and physiologic function

Product Information:Contains: 60 Tablets

Contents:Each tablet supplies:

Neonatal Kidney Concentrate (from bovine) 250 mg, Superoxide Dismutase (from vegetable culture) 20 mcg, Catalase (from vegetable culture) 20 mcg.

RECOMMENDATION: One (1) tablet one (1) to three (3) times each day as a dietary supplement or as otherwise directed by a health care professional.

Product Information:Capsules per bottle: 60

Contents:Each tablet supplies:

Neonatal Pituitary/Hypothalamus Complex Concentrate (from bovine) 40 mg, Superoxide Dismutase (from vegetable culture) 20 mcg, Catalase (from vegetable culture) 20 mcg.

RECOMMENDATION: One (1) tablet one (1) to three (3) times each day as a dietary supplement or as otherwise directed by a health care professional.

Basic concepts and physiologic function

Immune function declines with age and in certain disease states. It appears to be related to the decline in production of hormones and growth factors from the thymus gland. Thus, thymus gland extracts have been used to support optimal immune function.

We invite you to see the clinical trial published by Jankovic et al. Immunorestorative effects in elderly humans of lipid and protein fractions from the calf thymus: a double-blind study. Annals of the New York Academy of Sciences. 1988;521:247-59

Also see Longo F, Lepore L, Agosti E, Panizon F.[Evaluation of the effectiveness of thymomodulin in children with recurrent respiratory infections] Pediatr Med Chir. 1988 Nov-Dec;10(6):603-7. Italian.

Product Information: Contains: 60 tablets

Contents:Each tablet supplies:

Neonatal Thymus Concentrate (from bovine) 125 mg, Superoxide Dismutase (from vegetable culture) 20 mcg, Catalase (from vegetable culture) 20 mcg.

RECOMMENDATION: One (1) tablet one (1) to three (3) times each day as a dietary supplement or as otherwise directed by a health care professional.

Other Ingredients: Water and Acacia Emulsifier base and sesame oil

Basic concepts and physiologic function

Vitamin D has a well-established role in calcium homeostasis and the maintenance of healthy bone.

Biotics’ Bio-D-Mulsion has excellent absorption due to our unique emulsification process. Our previous research with emulsification showed that absorption of CoQ-10 was greatly increased by emulsification, resulting in higher serum levels at improved cost-effectiveness.*

Recent articles indicate that the prevalence of vitamin D deficiency is much higher than previously recognized (more than 90% in patients with chronic pain, according to a recent study published by the Mayo Clinic), and that vitamin D supplementation is much safer than previously recognized. The recent studies by Al Faraj (2003), Vieth, Chan, and MacFarlane (2001), and Heaney et al (2003) all used daily doses of 4,000 IU per day or more with no evidence of adverse effects.

Recent articles have also suggested that vitamin D may have a role in the prevention and treatment of many chronic diseases. We are clearly on the verge of a paradigm shift with regard to our understanding and clinical use of vitamin D.

Product Information:

Servings per bottle: 750

Contents:

Each drop supplies 400 IU of vitamin D in the form of cholecalciferol.

Additional information:

Introduction: While we are all familiar with the importance of vitamin D in calcium absorption and bone metabolism, many doctors and patients are not aware of the recent research on vitamin D and the widening range of therapeutic applications available for cholecalciferol, which can be classified as both a vitamin and a steroid hormone.(1) Additionally, while it was commonly assumed that the upper limit of toxicity was approximately 1,000 IU per day, we now know that the physiologic requirement of vitamin D may be as high as 4,000 IU per day, which is approximately half of the 10,000 IU that can be produced endogenously with full-body sun exposure.(2)

Vitamin D deficiency and musculoskeletal pain Vitamin D deficiency causes dull, achy musculoskeletal pain that this incompletely responsive to both pharmacologic and manual treatments. The pain may be widespread or confined to a particular area, most commonly the low back and lumbar spine. The mechanism by which this pain is produced has been clearly elucidated: 1) vitamin D deficiency causes a reduction in calcium absorption, 2) production of parathyroid (PTH) hormone is increased to maintain blood calcium levels, 3) PTH results in increased urinary excretion of phosphorus, which leads to hypophosphatemia, 4) insufficient calcium phosphate results in deposition of unmineralized collagen matrix on the endosteal (inside) and periosteal (outside) of bones, 5) when the collagen matrix hydrates and swells, it causes pressure on the sensory-innervated periosteum resulting in pain.(3) Indeed, several clinical investigations have recently shown that vitamin D deficiency is particularly common among people with musculoskeletal pain.(4, 5)

Non-musculoskeletal manifestations of hypovitaminosis D Both the peripheral and central nervous systems have multiple sites of action for vitamin D, and it appears likely that vitamin D modulates serotonin and melatonin synthesis and metabolism. Alterations in vitamin D levels appear to explain, at least in part, the adverse psychological effects of sunlight deprivation, such as which occurs in winter.(6) Preliminary evidence suggests that vitamin D deficiency may also be particularly common among patients with inflammatory and autoimmune disorders, and that vitamin D may modulate inflammatory responses.(7, 8, 9)

Bio-D-Mulsion and the importance of micro-emulsification At Biotics Research Corporation, our vitamin D is micro-emulsified to enhance absorption. Independent clinical experience suggests that our micro-emulsion form of vitamin D provides significant improvements in serum levels of 25-OH-vitamin D following supplementation.(10) Each drop of Bio-D-Mulsion supplies a full 400 IU of vitamin D3, micro-emulsified for greater absorption and utilization - particularly important for those with malabsorption conditions. With an increased knowledge of the importance of maintaining adequate Vitamin D levels, many clinicians recommend supplementation and annual screening for 25-OH-Vitamin D levels, especially for patients at risk for deficiency and those who may benefit from supplementation.

Product Information: Contains: 100 Capsules

Contents: Each capsule supplies: Proprietary blend: 500 mg: Artemisia dracunculus (leaf), Tinospora cordifolia (stem), Equisetum arvense (stem), Thymus vulgaris (aerial part), Pau D’ Arco (inner bark), Sida cordifolia (aerial part), Olea europaea (leaf).

RECOMMENDATION: One (1) to two (2) capsules taken twice each day (immediately before breakfast and lunch) as a dietary supplement or as otherwise directed by a health care professional.

Our oil is prepared from certified organically grown flax seed which is cold pressed to preserve maximum nutritional benefits.

Flax oil is the richest source of the omega-3 essential fatty acid Alpha-Linolenic Acid (ALA), which comprises approximately 60% of the oil. Flax oil is also rich (~20%) in oleic acid, the main fatty acid found in olive oil. The remaining 20% of the oil is comprised of other fatty acids, primarily the essential omega-6 fatty acid linoleic acid.

Basic concepts and physiologic function

Alpha-linolenic acid is a nutritionally essential omega-3 fatty acid. Proper and frequent intake of omega-3 fatty acids is necessary for promoting healthy physiologic function, especially with regard to normalizing inflammation, cardiovascular health, and gene expression.

Product Information:Capsules per bottle: 100

Contents:Each capsule provides approximately:

550 mg of ALA, 160 mg of LA, 180 mg of oleic acid.

Basic concepts and physiologic function

Methionine is an amino acid, and it has historically been referred to as "vitamin U" particularly in the European research literature.

Product Information:Capsules per bottle: 90

Contents:Each tablet supplies: Vitamin A (as natural mixed carotenoids and palmitate) -2.5/1ratio) 3,500 IU, Gamma Oryzanol (from rice bran) 100 mg, Chlorophyllins (from Mulberry leaves) 20 mg, Vitamin U complex (as dl-Methionine, methylsulfonium chloride) 10 mg, Superoxide Dismutase (from vegetable culture) 15 mcg, Catalase (from vegetable culture) 15 mcg.

RECOMMENDATION: One (1) tablet taken three (3) times each day as a dietary supplement or as otherwise directed by a health care professional.

Formulated for Biotics Research by Jonathan V. Wright, M.D. and Alan R. Gaby, M.D., leaders in the field of nutritional science.

Wide clinical use in the U.S.A. 1000 mcg chromium (as aspartate). Chromium is essential for glucose metabolism.

Contains both Niacin, a vital component of GTF (Glucose Tolerance Factor) and Niacinamide, necessary for producing NAD (Nicotinamide Adenine Dinucleotide) in insulin secreting pancreatic B cells.

Formulated with a uniquely high amount of biotin - 3000 mcg. Biotin is essential for glucose phosphorylation by hepatic glucokinase, the first step in glucose utilization

Effective regulation of blood glucose has important implications for health. Even mild disruptions of glucose homeostasis can have adverse consequences. Chronic diabetes may result in cardiovascular disease, neuropathy, blindness, or renal failure. Hypoglycemia (also called reactive hypoglycemia or dysinsulinism), though not general associated with the organ damage seen in diabetes, can be responsible for a number of troublesome physical and psychological symptoms.

The human body possesses a complex set of checks and balances to maintain blood glucose concentrations within a narrow range. Blood sugar control is influenced by the pituitary, thyroid, and adrenal glands, as well as by the pancreas, liver, kidney, and even skeletal muscle.

Glucose homeostasis also depends on the presence of a wide range of micronutrients. In the typical American diet, high in refined and processed foods, many of these micronutrients are in short supply. In addition, some individuals with blood sugar disorders may have a special dietary need for higher amounts of one or more micronutrients.

RECOMMENDATION: Two (2) capsules, three (3) times per day.

Warning: If you are taking diabetes medication, do not use GlucoBalance without professional supervision.

Product Information:Capsules per bottle: 90

Function and Contents

GlucoBalance contains all of the nutrients that are essential for proper glucose metabolism.

Serving Size 6 Capsules Amount % Daily Servings Per Container 15 Per Serving Values: Vitamin A (as retinyl acetate) 5000 IU 100%, Vitamin C (as calcium ascorbate and ascorbic acid) 500 mg 833%, Vitamin D (as cholecalciferol) 100 IU 25%, Vitamin E (as d-alpha tocopheryl acetate) 400 IU 1333%, Thiamin (B1) (as thiamin mononitrate) 50 mg 3333%, Vitamin (B2) (as riboflavin) 25 mg 1470%, Niacin (as niacinamide and niacin) 150 mg 750%, Vitamin B6 (as pyridoxine hydrochloride) 30 mg 1500%, Folic Acid 800 mcg 200%, Vitamin B12 (as cobalamin) 50 mcg 833%, Biotin 3000 mcg 1000%, Pantothenic Acid (as calcium pantothenate) 100 mg 1000%, Calcium (as ascorbate, citrate and carbonate) 200 mg 20%, Magnesium (as aspartate, citrate and oxide) 400 mg 100%, Zinc (as zinc picolinate and zinc citrate) 30 mg 200%, Selenium (as selenomethionine) 150 mcg 214%, Copper (as copper gluconate) 2 mg 100%, Manganese (as manganese aspartate) 20 mg 1000%, Chromium (as chromium aspartate) 1000 mcg 833%, Potassium (as potassium aspartate) 99 mg 3%, Vanadium (as vanadium aspartate) 20 mcg *.

Research and additional information: The following nutrients are particularly important when considering blood sugar disorders:

Chromium

The effect of chromium on glucose metabolism apparently requires its conversion to glucose tolerance factor (GTF), a low-molecular-weight compound that contains chromium, niacin (nicotinic acid), glycine, glutamic acid, and cysteine. GTF, has been shown to potentiate the action of insulin at the cellular level. (1,4)

Tissue chromium levels were found to decline with age in Americans. (2) In other studies, including one by the U.S. Department of Agriculture, more than 50% of people consumed less than the lower level of chromium recommended by the National Academy of Sciences, Nutritional Research Council. (3, 37) Chromium aspartate is a well-utilized form of supplemental chromium being solubilized at a wide range of ph. The amounts of chromium used in most clinical trials (*150 to 200 ug/day) are apparently inadequate for some patients, even when more efficient Chromium compounds are used. Larger amounts of chromium, such as 500 to 1,000 ug/day, have often had a greater benefit. (4)

Niacin and Niacinamide

As a component of glucose tolerance factor, niacin plays an important role in carbohydrate metabolism. Many refined foods consumed by Americans are depleted of niacin. Grains and other foods that are “enriched” usually contain added niacinamide, which apparently cannot be converted by the human body into niacin. In addition, many vitamin supplements contain niacinamide, rather than niacin. Although niacinamide is capable of performing most of the functions of vitamin B3, a small amount of niacin seems to be necessary for the synthesis of GTF. (5) Both niacin and niacinamide may also be important for blood sugar control through a mechanism unrelated to GTF. As precursors to NAD, which is an important metabolite concerned with intracellular energy production, niacin and niacinamide may prevent the depletion of NAD in pancreatic B cells.

Biotin

The initial step in glucose utilization by the cell is its phosphorylation, mediated by the biotin-dependent enzyme hepatic glucokinase. Thus adequate biotin intake is required to initiate intracellular glucose into the cell. (6)

Biotin may also play a role in stabilizing blood sugar levels through biotin-dependent enzymes acetyl Co A carboxylase and pyruvate carboxylase. (37) Thus biotin deficiency should be avoided in those with blood sugar disorders.

Pyridoxine (vitamin B6)

Serum vitamin B6 levels were below normal in 25% of 518 diabetics. (7) Particularly where peripheral neuropathy is present, the inadequate B6 intake should be contemplated.(8)

Copper

Because the typical American diet contains only about half of the RDA (2 mg/day) for copper (9,36), deficiency of this mineral may be common. Copper is involved with insulin binding, and copper deficiency in mammals may be reflected in increased glucosylated hemoglobin, indicative of chronically raised blood sugar levels. (10)

Magnesium

The American diet is often low in magnesium. Dietary surveys have shown that 80-85% of American women consume less than the RDA for the mineral. (11) Daily magnesium intake in two other studies was only about two-thirds of the RDA. (12,13,36) This may be particularly relevant in diabetics, where magnesium deficiency is thought to play a role in the development of insulin resistance. (14) Serum magnesium has been found to be significantly lower in many diabetics (15), therefore, it is reasonable to make sure that diabetics have adequate dietary intake of magnesium. Low magnesium levels may also be associated with hypoglycemia. (16)

Zinc

Zinc is involved both with insulin synthesis by pancreatic B cells (17) and insulin binding to liver and adipose tissue cells. (18,19) People with zinc deficiency may have significantly higher glucose levels and lower insulin levels than similar patients without zinc deficiency. (20)

Vitamin C (ascorbic acid)

Ascorbic acid levels may be lower in diabetics than controls (22) and patients with inadequate ascorbic acid levels may be found to have abnormal blood sugar curves. (23) In addition, ascorbic acid may compete with glucose for transport across cell membranes, (24) so that in hyperglycemia, ascorbic acid transport into the cell may be inhibited. (25)

Ascorbic acid deficiency may allow sorbitol to accumulate in erythrocytes, which may pre-dispose diabetics to certain types of end-organ damage. (26) Care should be taken to ensure that those with blood sugar abnormalities have adequate ascorbic acid intake.

Manganese

Manganese is a cofactor for certain enzymes involved in the inter-mediary metabolism of carbohydrates. In addition, the concentration of manganese in the pancreas is approximately ten times higher than in other organs. (27)

The optimal intake of manganese is not known but at least half of the manganese is lost when whole grains are replaced by refined flour. (29) The American diet may be low in manganese. (36)

Both B12 and folate are involved in a number of different steps in carbohydrate metabolism and the incidence of B12 deficiency was significantly greater in a series of diabetics than in the general population. (30) Folate is involved with gluconeogenesis as a cofactor with key enzymes in the liver and small intestine. (31) Deficiency of either B12 or folate is to be avoided in those with blood sugar abnormalities.

Vitamin B1 (thiamin)

Central to carbohydrate metabolism and Krebs Cycle function is adequate thiamin levels, and diabetics are more often deficient in thiamin. (32) Care should be taken to ensure that thiamin intake is adequate in those with diabetes and hypoglycemia.

Carnitine

Carnitine is involved as part of a vital transport mechanism of fat metabolism in which fat enters energy production pathway. Carnitine supplementation may be considered in those with blood sugar abnormalities.

Vanadium

Vanadate is an oxidized form of vanadium. Due to possible insulinotropic effects of vanadate (33), inadequate amounts of this trace mineral is undesirable in those with blood sugar abnormalities.

Vitamin E and Selenium

Vitamin E and selenium are essential nutritional factors which act as antioxidants and may be involved in glucose balance. (34, 35) As many complications associated with diabetes may be related to excess free radical activity, prudence demands that adequate selenium and vitamin E be supplied in the diabetic diet.

Basic concepts and physiologic function

This product contains a variety of nutrients and glandulars to promote optimal blood glucose homeostasis.

Product Information:Capsules per bottle: 90

Contents:

Three (3) tablets supply:

Vitamin A (as natural mixed carotenoids and palmitate) 5,000 IU, Vitamin C (as calcium, magnesium and niacinamide ascorbates) 120 mg, Vitamin D (as cholecalciferol) 200 IU, Vitamin E (as d-alpha tocopheryl acetate) 30 IU, Vitamin K (as phytonadione) 10 mcg, Thiamin (B1) (as cocarboxylase) 11 mg, Riboflavin (B2) (as riboflavin-5-phosphate) 11 mg, Niacin (as niacinamide ascorbate) 25 mg, Vitamin B6 (as pyridoxal-5-phosphate) 32 mg, Folic Acid 400 mcg, Vitamin B12 (as resin bound cobalamin) 100 mcg, Biotin 300 mcg, Pantothenic Acid (as calcium pantothenate) 100 mg, Calcium (as calcium citrate and ascorbate) 40 mg, Magnesium (as magnesium aspartate and ascorbate) 40 mg, Zinc (as zinc gluconate) 15 mg, Selenium (from vegetable culture) 20 mcg, Copper (as copper gluconate) 2 mg, Manganese (as manganese gluconate) 5 mg, Chromium (from vegetable culture) 100 mcg, Potassium (as potassium chloride) 99 mg, Vanadium (from vegetable culture) 10 mcg Inositol 35 mg, Choline (as choline bitartrate) 35 mg, Neonatal Adrenal complex (from bovine) 40 mg, Neonatal Pituitary/Hypothalamus complex (from bovine) 20 mg, Neonatal Pancreas (from bovine) 15 mg, Neonatal Liver (from bovine) 15 mg, Neonatal Brain (from bovine) 5 mg, Lamb Intestine (ovine) 5 mg, L-Lysine HCI 40 mg, L-Methionine 20 mg, Superoxide Dismutase (from vegetable culture) 20 mcg, Catalase (from vegetable culture) 20 mcg.

RECOMMENDATION: One (1) to three (3) tablets each day as a dietary supplement or as otherwise directed by a health care professional.

Basic concepts and physiologic function

This product is designed to support proper gastric function by increase sing the acid content (reducing pH) of the stomach to promote optimal food digestion and sterilization of consumed foods.

Pepsin and pancreatin are sources of digestive enzymes to promote hydrolysis of proteins into amino acids.

Product Information:Tablets per bottle: 90

Contents: Each tablet supplies:

Vitamin B6 (as pyridoxine HCI) 2 mg, Betaine HCI 150 mg, Glutamic Acid (as L-Glutamic acid HCI) 50 mg, Ammonium Chloride 35 mg, Pancreatin 4X* (from porcine) 10 mg. *Pancreatin 4X is coated for protection from the acidic stomach environment. Pepsin (1:10,000) 10 mg.

RECOMMENDATION: One (1) tablet with each meal as a dietary supplement or as otherwise directed by a health care professional.

Basic concepts and physiologic function

Arabinogalactans are complex carbohydrates that resist human digestion and which have been shown to promote the growth of Lactobacillus in humans.

Product Information:Grams per bottle: 100

Contents:

IAG supplies Arabinogalactans—long, densely branched, high molecular polysaccharides derived from Larch trees.

RECOMMENDATION: One (1) teaspoon each day as a dietary supplement or as otherwise directed by a health care professional.

Basic concepts and physiologic function

This product contains a synergistic blend of vitamins, minerals, enzymes, botanicals and glandulars and is intended to promote optimal immune function, particularly during times of illness or stress.

Product Information: Tablets per bottle: 90

Contents:Two (2) tablets supply:

Vitamin A (as palmitate and natural mixed carotenoids) 6,667 IU, Vitamin C (as calcium and magnesium ascorbates) 200 mg, Vitamin E (as d-alpha tocopheryl acetate) 30 IU, Thiamin (B1) (as cocarboxylase) 10 mg, Riboflavin (B2) (as riboflavin-5-phosphate) 15 mg, Niacin (as niacinamide) 20 mg, Vitamin B6 (as pyridoxal-5-phosphate) 15 mg, Pantothenic Acid (as calcium pantothenate) 25 mg, Zinc (as zinc gluconate) 30 mg, Selenium (from vegetable culture and selenomethionine) 50 mcg, Copper (as gluconate) 1 mg, Manganese (as gluconate) 2 mg, Neonatal Adrenal complex (from bovine) 20 mg, Neonatal Thymus (from bovine) 60 mg, Neonatal Spleen (from bovine) 60 mg, Neonatal Liver (from bovine) 60 mg, Neonatal Pancreas (from bovine) 60 mg, Parotid (from bovine) 40 mg, Lymph (from bovine) 60 mg, Placenta (from bovine) 20 mg, Trypsin & alpha chymotrypsin (from porcine) 25 mg, L-Lysine HCI 100 mg, Coenzyme Q10 (emulsified) 1 mg, Citrus Bioflavonoids 50 mg, Superoxide Dismutase (from vegetable culture) 60 mcg, Peroxidases (catalase and glutathione peroxidase from vegetable culture) 400 Units, Proprietary blend: 110 mg: Echinacea (root), Capsicum annuum (fruit), Chlorophyllins, OOrganik-15™, Lactobacillus acidophilus (DDS-1)

RECOMMENDATION: Two (2) tablets each day as a dietary supplement or as otherwise directed by a health care professional.

Basic concepts and physiologic function

Iodine is necessary for healthy thyroid function.

Product Information: 2 ounces per bottle: 1200 drops

Contents:Each drop supplies:

Iodine (as potassium iodide) 75 mcg.

RECOMMENDATION: One (1) drop one (1) to two (2) times each day as a dietary supplement or as otherwise directed by a health care professional.

Each drop of Bio-K-Mulsion™ supplies 500mcg of vitamin K, micro-emulsified for greater bioavailability. This is particularly important for those with malabsorbtion syndromes, as they tend to be vitamin K deficient.

Vitamin K supplementation has been shown to have a positive impact on bone density and calcium loss. One study demonstrated a reduction in calcium loss by up to 50% in osteoporotic individuals.

Osteocalcin, the most abundant non-collagenous protein in bone, is vitamin K dependent. It is synthesized by osteoblast during bone matrix formation and incorporated into bone.

Vitamin K is an essential co-factor for gamma-carboxylase enzymes. In the absence of vitamin K, g-carboxylation does not occur. Undercarboxylation of osteocalcin adversely affects its capacity to bind to bone mineral. In other words, it negatively impacts bone calcification.

Vitamin K supplementation is generally contraindicated in patients who are taking coumadin/warfarin. Pregnant women should avoid supplementation with vitamin K is doses exceeding 65 mcg unless directed by a doctor.

Product Information: Drops per bottle: 950

Contents: Each drop contains 500 mcg as K1--phytonadione.

Basic concepts and physiologic function

Potassium is a necessary electrolyte for the proper function of nerve and muscle cells in particular.

Product Information: Tablets per bottle: 100

Contents: Each tablet supplies:

Potassium (as potassium gluconate, potassium chloride and potassium aspartate) 99 mg, Superoxide Dismutase (from vegetable culture) 15 mcg, Catalase (from vegetable culture) 15 mcg.

RECOMMENDATION: One (1) tablet one (1) to three (3) times each day as a dietary supplement or as otherwise directed by a health care professional.

Lactobacillus Acidophilus (DDS-1) and Bifidobacterium Bifidus

Basic concepts and physiologic function

The total surface of the gastrointestinal tract including the stomach, small intestine and large intestine is estimated to be close to the size of a football field. Obviously this large surface area represents an enormous exposure of the body to the external environment, and therefore relatively minor alterations in gastrointestinal function can have profound effects on systemic health.

Product Information:Capsules per bottle: 100

Contents: (Lactobacillus Acidophilus (DDS-1) and Bifidobacterium Bifidus) Each tablet supplies: Proprietary blend: 148 mg Vegetable Culture concentrate. Lactobacillus acidophilus (DDS-1), Bifido bacterium. 50 million freeze dried Lactobacillus when packaged.

RECOMMENDATION: One (1) tablet with each meal as a dietary supplement or as otherwise directed by a health care professional. Refrigerate after opening.